Diabetes-induced cerebrovascular dysfunction: role of poly (ADP-ribose) polymerase
DM Arrick, GM Sharpe, H Sun, WG Mayhan - Microvascular research, 2007 - Elsevier
Our goal was to identify the role of poly (ADP-ribose) polymerase (PARP) in cerebrovascular
dysfunction in Type 1 diabetes mellitus (T1D). In a first series of studies, rats were assigned
to nondiabetic and diabetic (streptozotocin; 50 mg/kg IP) groups. Two to three months after
injection of streptozotocin, we examine in vivo responses of pial arterioles to nitric oxide
synthase (NOS)-dependent (adenosine diphosphate (ADP), acetylcholine and histamine)
and-independent (nitroglycerin) agonists. After the initial examination of reactivity to the …
dysfunction in Type 1 diabetes mellitus (T1D). In a first series of studies, rats were assigned
to nondiabetic and diabetic (streptozotocin; 50 mg/kg IP) groups. Two to three months after
injection of streptozotocin, we examine in vivo responses of pial arterioles to nitric oxide
synthase (NOS)-dependent (adenosine diphosphate (ADP), acetylcholine and histamine)
and-independent (nitroglycerin) agonists. After the initial examination of reactivity to the …
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